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Systemic messenger RNA replacement therapy is effective in a novel clinically relevant model of acute intermittent porphyria developed in non-human primates | Gut

ADCs targeting TROP2, HER2, HER3, c-MET, B7H3, and CEACAM5 are either approved or under investigation for the treatment of NSCLC, and similar agents against other targets are showing promise in SCLC patients (90)

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(Here nutrient dependency refers to the phenomenon wherein metabolic reprogramming renders cancer cells to be highly dependent on certain nutrients for survival and growth, such that removal of such nutrients will selectively kill or halt the growth of cancer cells that are dependent on these nutrients while having less harmful effects on other cancer cells or normal cells.) In this review, we will summarize how diverse regulation of SLC7A11 expression and its transporter activity governs ferroptosis